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Familial gastrointestinal stromal tumours with germline mutation of the KIT gene

✍ Scribed by Nishida, Toshirou; Hirota, Seiichi; Taniguchi, Masahiko; Hashimoto, Koji; Isozaki, Koji; Nakamura, Harumi; Kanakura, Yuzuru; Tanaka, Tomoyuki; Takabayashi, Arimichi; Matsuda, Hikaru; Kitamura, Yukihiko


Book ID
109487901
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
140 KB
Volume
19
Category
Article
ISSN
1061-4036

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## Abstract Somatic, activating mutations of __KIT__ or __PDGFRA__ are early oncogenic events in the majority of sporadic gastrointestinal stromal tumors (GISTs). Also a number of families with GISTs have been described in recent years. The familial GIST syndrome is a rare autosomal dominant disord