β Scribed by Ori Elkayam; Dan Caspi; Rafael Segal; Chaim Brautbar; Eldad Ben-Chetrit; Michael Yaron
No coin nor oath required. For personal study only.
Erythema nodosum (EN) is a hypersensitivity reaction associated with many diseases. We describe a family in which 4 sisters had acute or recurrent EN. HLA typing showed a common haplotype in the affected members of the family. A review of familial EN and HLA distribution in EN is presented.
Erythema nodosum (EN) is considered to be an acute hypersensitivity reaction. It may occur alone or in association with various other diseases or certain medications (1,2). There have been a few reports of familial EN, mostly occurring during tuberculosis (TB) infection (3). We recently studied a family in which all 4 sisters developed EN after pharyngitis. In 3 of them, EN was recurrent. The family, which was studied following examination of 1 of our patients (AP), who presented with acute EN, is discussed herein.
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