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Familial defective apolipoprotein B-100: detection in the United Kingdom and Scandinavia, and clinical characteristics of ten cases

✍ Scribed by Anne Tybjærg-Hansen; John Gallagher; John Vincent; Richard Houlston; Philippa Talmud; Alison M. Dunning; Mary Seed; Anders Hamsten; Steve E. Humphries; Nicholas B. Myant


Book ID
118896349
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
780 KB
Volume
80
Category
Article
ISSN
0021-9150

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Familial ligand-defective apolipoprotein
✍ JP Rabès; M Varret; B Saint-Jore; D Erlich; G Jondeau; M Krempf; P Giraudet; C J 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB

## Communicated by Michel Goossens Familial ligand-defective apolipoprotein B-100 (FDB) is an autosomal dominant disorder leading to plasma LDL cholesterol elevation and coronary artery disease (CAD). Two specific mutations in the APOB gene-R3500Q and R3531C-induce FDB. We report an original metho