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Familial Breast Cancers without Mutations in BRCA1 or BRCA2 Have Low Cyclin E and High Cyclin D1 in Contrast to Cancers in BRCA Mutation Carriers

✍ Scribed by Mittendorf, E.A.

Book ID
123339377
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
61 KB
Volume
20
Category
Article
ISSN
1043-321X

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We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie