𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Familial and metachronous malignant lymphoma: Absence of constitutional p53 mutations

✍ Scribed by P�tzsch, Claudia; Schaefer, Hans-Eckart; L�bbert, Michael

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
76 KB
Volume
62
Category
Article
ISSN
0361-8609

No coin nor oath required. For personal study only.

✦ Synopsis

Familial and metachronous aggregations of malignant lymphoma are well-documented, but the molecular basis of a predisposition for development of lymphoma is as yet unclear. Malignant lymphomas have been described as part of the spectrum of neoplasias in Li-Fraumeni syndrome (LFS), which is associated with constitutional mutations of p53. However, p53 germline mutations have also, albeit less frequently, been described in patients not fitting the clinical definition of LFS. To clarify whether a genetic predisposition for lymphoma is associated with constitutional p53 mutations, DNA from normal blood lymphocytes of 12 lymphoma patients with a family history of lymphoma and/or with metachronous lymphoma (median age 37 years) was examined for mutations of p53 exons 4-8. One patient had four first-degree relatives with Hodgkin's disease, acute leukemia, and carcinomas, but the family history did not fulfill criteria of LFS. Four patients with Hodgkin's disease were diagnosed with metachronous non-Hodgkin's lymphoma as a second malignant neoplasm. No constitutional p53 mutations were detected in any of these patients, implying that outside the clinical spectrum of LFS, constitutional p53 mutations are rare in patients with lymphomas. Am.

📜 SIMILAR VOLUMES

Absence of p53 mutations in benign and p
Absence of p53 mutations in benign and pre-malignant male genital lesions with over-expressed p53 protein
✍ Katariina Castrén; Kirsi Vähäkangas; Eini Heikkinen; Annamari Ranki 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 236 KB 👁 2 views

Mutations of the tumor-suppressor gene p53 are common in epithelial tumors. Clonal mutations of p53 have been found in cervical and vulvar carcinomas negative for human papillomavirus (HPV), though at least in cervical cancer HPV infection and p53 mutations are not mutually exclusive. We have previo

Overexpression and mutations of p53 in m
Overexpression and mutations of p53 in metastatic malignant melanomas
✍ Arndt Hartmann; Hagen Blaszyk; Julie S. Cunningham; Renee M. McGovern; Jennifer 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 495 KB 👁 2 views

Alterations of the p53 tumor suppressor gene are the most frequent genetic abnormalities in human malignancies, but the role of p53 in the etiology of malignant melanomas is unclear. Fifty unselected malignant melanomas were analyzed for p53 overexpression by immunohistochemistry using 3 monoclonal

Ki-ras gene mutations and absence of p53
Ki-ras gene mutations and absence of p53 gene mutations in spontaneous and urethane-induced early lung lesions in CBA/J mice
✍ Maite Cazorla; Luis Hernández; Pedro L. Fernández; Àngels Fabra; Miguel A. Peina 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 396 KB

Ki-ras and p53 genes are involved in human lung carcinogenesis; however, the role of these genes in experimental lung tumors is not well known. In our study, the CBA/J mouse strain was used to investigate the presence of Ki-ras and p53 alterations in lung carcinogenesis of spontaneous tumors and tum

Molecular pathology of primary and metas
Molecular pathology of primary and metastatic ductal pancreatic lesions : Analyses of mutations and expression of the p53, mdm-2, and p21/WAF-1 genes in sporadic and familial lesions
✍ Bruce A. Ruggeri; Lingyi Huang; David Berger; Hong Chang; Andres J. P. Klein-Sza 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 477 KB 👁 1 views

Histologically confirmed specimens of primary (n Å 136) and metastatic icine, Allegheny University of the Health Sci-(n Å 23) sporadic and familial ductal pancreatic adenocarcinoma lesions were ences,

Rare mutations of p53, Ki-ras, and β-cat
Rare mutations of p53, Ki-ras, and β-catenin genes and absence of K-sam and c-erbB-2 amplification in N-methyl-N′-N-nitrosoguanidine–induced rat stomach cancers
✍ Yoshikazu Hirayama; Kuniko Wakazono; Masami Yamamoto; Motoo Kitano; Masae Tatema 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB

Rat stomach cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) have been widely used as a model for human stomach cancers of the differentiated type. However, there has been little information regarding their molecular basis. In this study, we examined the genetic alterations reported in