Familial amyloid polyneuropathy (FAP) is a form of hereditary generalized amyloidosis. Liver tissue explanted from FAP patients has normal structure and function, except for the production of amyloidogenic variant transthyretin (TTR), and domino liver transplantation (DLT) using grafts from FAP pati
Familial amyloid polyneuropathy in Taiwan: Identification of transthyretin variant (Leu55 → Pro)
✍ Scribed by Dr. Kanji Yamamoto; Dr. Shih-Pin Hsu; Dr. Kunihiro Yoshida; Dr. Shu-ichi Ikeda; Dr. Masamitsu Nakazato; Dr. Kazutaka Shiomi; Dr. Shaw-Yi Cheng; Dr. Kenichi Furihata; Dr. Ichiro Ueno; Dr. Nobuo Yanagisawa
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 467 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0148-639X
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In patients with familial amyloidotic polyneuropathy (FAP), heart complications are prognostic factors for mortality and morbidity after liver transplantation (LT). However, only a few studies have analyzed the development of arrhythmia in transplant patients with FAP. We investigated the developmen
Familial amyloidotic polyneuropathy is an inherited form of amyloidosis associated with a mutant form of a protein called transthyretin. The Methionine-30 variant is the most frequent mutation observed. This disorder is caused by deposition of this protein as amyloid in several organs, such as the h