✦ LIBER ✦
Familial alzheimer's disease (FAD): co-segregation between alleles at the D21S11 DNA marker and the FAD gene in a particular pedigree
✍ Scribed by F. David; F. Clerget; G. Lucote
- Book ID
- 104718337
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 262 KB
- Volume
- 235
- Category
- Article
- ISSN
- 0340-5354
No coin nor oath required. For personal study only.
✦ Synopsis
Segregation studies of Alzheimer's disease (AD) gene and a cloned DNA probe (D21S11), which detects an EcoRI restriction fragment length polymorphism for a sequence located in the medial part of the long arm of chromosome 21, are reported in a large pedigree, in which AD is transmitted as an autosomal dominant mendelian trait. In this pedigree, the AD gene co-segregation with one of the alternative alleles at the probe raises the possibility of using such a marker for presymptomatic diagnosis of individuals at risk for the disease.