## Abstract A false discovery occurs when a researcher concludes that a marker is involved in the etiology of the disease whereas in reality it is not. In genetic studies the risk of false discoveries is very high because only few among the many markers that can be tested will have an effect on the
False discoveries in genome scanning
β Scribed by Eugene I. Drigalenko; Robert C. Elston
- Book ID
- 101264960
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 76 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
β¦ Synopsis
Methods of multiple comparisons were applied to linkage analysis in the case of genome scanning. Data for Problem 2A were used. p-Values were calculated for all 440,400 possible tests of linkage. Plots of distribution functions and false discovery rate are shown.
π SIMILAR VOLUMES
Researchers conducting gene expression microarray experiments often are interested in identifying genes that are di erentially expressed between two groups of specimens. A straightforward approach to the identiΓΏcation of such "di erentially expressed" genes is to perform a univariate analysis of gro