Fallacy in concluding there are zero-order kinetics from blood level and urinary excretion data
✍ Scribed by John G. Wagner
- Book ID
- 102913331
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 811 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
tions containing more than 40% DMSO does not prevent damage to erythrocytes and/or the precipitation of blood components. It appears that aqueous solutions containing more than 40y0 DMSO would be unsafe as a vehicle for intravenous preparations.
To determine the effect of a ternary solvent system on erythrocytes, hemolysis experiments were run at 37' in solutions containing 20% DMSO, 0.9% sodium chloride, and various amounts of either propylene glycol or polyethylene glycol 300 (PEG 300). Solutions containing 0.0 to 30y0 propylene glycol did not hemolyze red blood cells, however, complete hemolysis with slight discoloration took place in those solutions containing more than 30% propylene glycol. Hemolysis did not take place in solutions containing 0.0 to 20% PEG 300; however, when blood was placed in solutions containing 25% or more PEG 300, the solutions became greenbrown, and a brown precipitate formed. In these ternary solvent systems, the addition of DMSO did not alter the critical concentrations (in 0.9% saline) (2, 3) at which propylene glycol and PEG 300 have been reported to hemolyze red blood cells. The damaging effect of the glycols appeared to be solely dependent on their concentration in solution,
Journal of Pharmaceutical Sciences
and there was no additive effect contributed by the DMSO present.