FAK Signaling in Neoplastic Disorders : A Linkage between Inflammation and Cancer
β Scribed by NAING NAING MON; SATOKO ITO; TAKESHI SENGA; MICHINARI HAMAGUCHI
- Book ID
- 111480647
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 257 KB
- Volume
- 1086
- Category
- Article
- ISSN
- 0890-6564
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The authors are grateful to Dr. Henry Burger, of Melbourne, .4ustralia, for his helpful assistance in the preparation of the manuscript and his advice. 'They are also grateful for the technical assistance of Miss Simone Gaspard, Mrs. llalou Debruche, and hlrs. Yvonne Vrindts. They are also very grat
## Abstract In the United States there are 225,000 new cases of invasive breast cancer annually, and at least 50,000 women are diagnosed with ductal carcinoma in situ (DCIS). Breast cancer is a collection of disorders of mammary epithelial cells with distinct pathological characteristics and divers
## Abstract In metastatic cancer, high expression levels of vitronectin (VN) receptors (integrins), FAK, and ERK5 are reported. We hypothesized that integrinβmediated ERK5 activation via FAK may play a pivotal role in cell adhesion, motility, and metastasis. ERK5 and FAK phosphorylation when metast