๐”– Bobbio Scriptorium
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Failure to Release Iron from Transferrin in a Chinese Hamster Ovary Cell Mutant Pleiotropically Defective in Endocytosis

โœ Scribed by Richard D. Klausner, Jos Van Renswoude, Christoph Kempf, Krishnamurthy Rao, Judith L. Bateman and April R. Robbins


Book ID
124787651
Publisher
Rockefeller University Press.
Year
1984
Tongue
English
Weight
805 KB
Volume
98
Category
Article
ISSN
0021-9525

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โœ Hugues J.-P. Ryser; Richard Mandel; Asteghik Hacobian; Dr. Wei-Chiang Shen ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 982 KB

Methotrexate (MTX) covalently linked to poly(L-lysine) [poly(Lys)] enters cells by endocytosis, is degraded in lysosomes and, upon liberation of small molecular methotrexate, is cytocidal to Chinese hamster cells in culture. This drug conjugate was used to select mutants resistant to MTX-poly(Lys),