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Failure to find a chromosome 18 pericentric linkage in families with schizophrenia

✍ Scribed by DeLisi, Lynn E. ;Lofthouse, Ray ;Lehner, Thomas ;Morganti, Carla ;Vita, Antonio ;Shields, Gail ;Bass, Nicholas ;Ott, Jurg ;Crow, Timothy J.

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 322 KB
Volume: 60
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320600609

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✦ Synopsis

Abstract

A recent report of a possible linkage of bipolar affective disorder to a pericentric region of chromosome 18 initiated the present investigation to search for a similar linkage in 32 families with schizophrenia. The results of a study using 5 markers mapped to this region show negative lod scores and only weak evidence for any linkage by nonparametric analyses. If the previously reported finding is a true positive linkage for bipolar disorder, then either it is unlikely to be related to the genetics of schizophrenia, or the proportion of families linked to this region is small. © 1995 Wiley‐Liss, Inc.

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Fig. 1. Nonparametric multipoint analysis of 72 families with schizophrenia/schizoaffective disorder by GENEHUNTER. a: triangles: affected females ‫ס‬ phenotype unknown, affected males ‫ס‬ affected; circles: affected males ‫ס‬ phenotype unknown, affected females ‫ס‬ affected; b: sample without 14 fe

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