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Failure to demonstrate alterations in gluconeogenesis in growth-retarded weanling rats with dorsomedial hypothalamic lesions

✍ Scribed by Dr. Lee L. Bernardis; Jack K. Goldman; Larry L. Bellinger

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
530 KB
Volume
2
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Bilateral electrolytic lesions were placed in the dorsomedial hypothalamic nuclei (DMN) of weanling male Sprague‐Dawley rats. Sham‐operated rats served as controls. After 22 days on lab chow and tap water ad libitum, the animals were injected with U‐^14^ C‐alanine 0.167 μC/μ moles intraperitoneally (5 μC and 30 μ moles/100 gm body weight) and sacrificed 2 hr later. There was no significant difference, in the incorporation of the label into total lipid, free fatty acids, glycogen, or tissue protein of both liver and diaphragm, between the DMN‐lesioned and the sham‐operated rats. Similarly, there was no significant difference in the incorporation into the plasma glucose or protein. It is concluded that in spite of profound alterations in both ponderal and linear growth and food intake, there is no disruption of normal gluconeogenesis in the weanling rat with DMN lesions.

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## Abstract Male rats received bilateral electrolytic lesions shortly after weaning in the ventromedial (VMN) and dorsomedial (DMN) hypothalamic nuclei, respectively. A third group of rats served as sham‐operated controls. The animals were subjected to intragastric preloading with 33% d‐glucose and