Failure to demonstrate a chromosome 2 deletion in adenomatous colorectal polyposis patients

Non-Hodgkin lymphoma related to heredita

Non-Hodgkin lymphoma related to hereditary nonpolyposis colorectal cancer in a patient with a novel heterozygous complex deletion in the MSH2 gene

✍ M. Pineda; E. Castellsagué; E. Musulén; G. Llort; T. Frebourg; S. Baert-Desurmon 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 811 KB

## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal disorder caused by mutations in DNA mismatch repair (MMR) genes. Tumors of the HNPCC‐spectrum are associated with microsatellite instability (MSI) and loss of MMR protein expression. Lymphomas are not considered to be HNP