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Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia

✍ Scribed by Susmita R Datta; Andrew McQuillin; Vinay Puri; Khalid Choudhury; Srinivasa Thirumalai; Jacob Lawrence; Jonathan Pimm; Nicholas Bass; Graham Lamb; Helen Moorey; Jenny Morgan; Bhaskar Punukollu; Gomathinayagam Kandasami; Simon Kirwin; Akeem Sule; Digby Quested; David Curtis; Hugh MD Gurling

Book ID: 119909312
Publisher: BioMed Central
Year: 2007
Tongue: English
Weight: 476 KB
Volume: 3
Category: Article
ISSN: 1744-9081
DOI: 10.1186/1744-9081-3-50

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## Abstract The chromosome 1q23.3 region, which includes the __RGS4__ gene has been implicated in genetic susceptibility to schizophrenia by two linkage studies with lod scores of 6.35 and 3.20 and with positive lod between 2.00 and 3.00 scores in several other studies. Reduced post mortem __RGS4__