## Abstract The highly encephalitogenic guinea pig peptide 68β88 has been used to develop an effective and reproducible model of protection in the Lewis rat. Doses as low as 0.1 nmol of peptide protected 70% of rats when injected intraperitoneally six and four weeks prior to challenge with 0.05 nmo
Failure of myelin basic protein to prevent or suppress experimental allergic encephalomyelitis in guinea pigs
β Scribed by G. A. Hashim
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 670 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0364-3190
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Studies from our laboratory have shown that region 69-84 (synthetic peptide S49S) of myelin basic protein (MBP) defines an encephalitogenic sequence for experimental allergic encephalomyelitis (EAE) in Lewis rats. The most potent EAE inducers are the guinea pig MBP (Gp-MBP) and region 69-84, known a
We have produced T cell lines with a Th2 phenotype in the presence of IL-4 and the glucocorticoid dexamethasone (DEX). IL-4 and DEX together were more effective in inducing a Th2 response than IL-4 alone. Myelin basic protein (MBP)-specific Th2 lines were obtained and their ability to induce experim