## Abstract Progressive multifocal leukoencephalopathy (PML) is a severe neurological disorder due to JC virus (JCV) infection. Pre‐diagnostic biological markers and risk factors for PML are not well understood. We conducted a case–control study nested within the Multicenter AIDS Cohort Study to ex
Failure of mefloquine therapy in progressive multifocal leukoencephalopathy: Report of two Japanese patients without human immunodeficiency virus infection
✍ Scribed by Zen Kobayashi; Miho Akaza; Yoshiyuki Numasawa; Shoichiro Ishihara; Hiroyuki Tomimitsu; Kazuo Nakamichi; Masayuki Saijo; Tomohiro Morio; Norio Shimizu; Nobuo Sanjo; Shuzo Shintani; Hidehiro Mizusawa
- Book ID
- 119304717
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 589 KB
- Volume
- 324
- Category
- Article
- ISSN
- 0022-510X
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Progressive multifocal leukoencephalopathy (PML) is a lytic infection of oligodendrocytes by the human papovavirus JC. Patients with defects in cell-mediated immunity are at risk for active disease: a usually lethal demyelination of the brain. PML develops in at least 4% of patients with the acquire
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