FAILURE OF LYMPHOCYTE TRANSFORMATION IN RESPONSE TO GAMMA-GLOBULINS IN RHEUMATOID ARTHRITIS
β Scribed by Kacaki, J.N.; Bullock, W.E.; Vaughan, J.H.
- Book ID
- 122553147
- Publisher
- The Lancet
- Year
- 1969
- Tongue
- English
- Weight
- 321 KB
- Volume
- 293
- Category
- Article
- ISSN
- 0140-6736
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## Abstract Patients who had active and severe rheumatoid arthritis (RA) were treated with human placentaβeluted gamma globulins (PEGG) composed of purified IgG eluted from trophoblastic cells. A control group of RA patients received retroplacental gamma globulins with no clinical effects. Seven of
## Abstract In vitro immunoglobulin synthesis by lymphocytes of patients with rheumatoid arthritis (RA) was enhanced by the addition of heatβaggregated human IgG. Stimulation occurred in the presence of fresh seropositive autologous plasma and was abolished by heat inactivation. By contrast, no sig
Placenta-eluted gamma globulins (PEGG) have been recently and successfully used in the treatment of patients with rheumatoid arthritis. PEGG, eluted at acid pH from large pools of human placentas, contained 99% IgG material. Sephacryl S300 gel filtration revealed a main fraction (76%) of native IgG