Failure of low molecular weight dextrans to alter the frequency of lung metastasis. Report on the V2 carcinoma of the rabbit
✍ Scribed by Sumner Wood Jr.; R. Robinson Baker; Jo H. Johnson
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 430 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
Three fractions of low molecular weight dextran (10,000, 40,000 and 70,000) were administered intravenously to Laboratory Lop rabbits before or after intravenous inoculation of ascitic V2 carcinoma cells. The frequency of pulmonary metastases was unaltered by dextran treatment. No extrapulmonary tumor was found in any instance. These findings are discussed i n relation to the studies of other investigators and the need for additional experiments employing a variety of tumors a n d hosts is emphasized.
HIS REPORT RECORDS THE FAILURE OF LOW
T molecular weight dextrans (M.W. 10,000, 40,000 and 70,000) to influence the frequency of pulmonary metastases resulting from the intravenous inoculation of ascitic V2 carcinoma cells in rabbits.
Low molecular weight dextran has been reported to coat the erythrocytes, platelets and vascular endothelium5 and has been used as a "desludging" or antithrombotic agent in a variety of experimental and clinical situations.7 Most of these experiments have been performed with traumatically induced venous thrombi. Such thrombi are initially and predominantly composed of platelets,lj contain little or n o fibrin15219 and may form in the absence of fibrinogen or fibrin.18 I t has been suggested that the function of dextran may be related to its action on platelets. Gurewich and Thomas17 have demonstrated that dextran is ineffective in preventing atraumatic venous thrombi whereas heparin is effective.
T h e mechanisms of metastasis formation from blood-borne tumor cells have been re-From the