Failure of Borrelia burgdorferi to survive in the skin of patients with antibiotic-treated Lyme disease
✍ Scribed by Berger, Bernard W.; Johnson, Russell C.; Kodner, Carrie; Coleman, Lisa
- Book ID
- 122764145
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 889 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1097-6787
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## Abstract ## Objective To compare the pattern of antibody responses to __Borrelia burgdorferi__ in patients with antibiotic‐refractory, antibiotic‐responsive, or non–antibiotic‐treated Lyme arthritis as an indirect measure of spirochetal persistence or eradication. ## Methods At least 3 serial
Spirochetal organisms were sought in 18 skin and 4 synovial membrane specimens obtained by biopsy from 22 Lyme disease patients. The presence of spirochetes in body tissues was histologically demonstrated in one patient with lymphadenosis benigna cutis, one patient with acrodermatitis chronica atrop
To determine whether Borrelia burgdorferi DNA may be detected in synovial tissue from patients with Lyme arthritis who have persistent synovial inflammation after antibiotic treatment. Methods. Synovial specimens obtained at synovectomy from 26 patients with antibiotic treatmentresistant Lyme arthr