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Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: Characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa

โœ Scribed by Rebecca Nofsinger; Ronald T. Borchardt


Book ID
112134480
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
274 KB
Volume
101
Category
Article
ISSN
0022-3549

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Factors that restrict intestinal cell pe
โœ Hui Ouyang; Weiqing Chen; Thomas E. Andersen; Bente Steffansen; Ronald T. Borcha ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 286 KB

The objective of this study was to determine the relative importance of metabolism by cytochrome P450 (CYP) enzymes versus efflux by P-glycoprotein (P-gp) in restricting the intestinal mucosal permeation of cyclic prodrugs (AOA-DADLE, CA-DADLE, OMCA-DADLE) of the opioid peptide DADLE (H-Tyr-D-Ala-Gl