Factors relevant for the induction of rejection by indirect recognition in a rat heart allograft model: effect of CTLA4Ig treatment on indirect alloactivation induced by immunization with donor MHC I peptides

Allograft survival following immunizatio

Allograft survival following immunization with membrane-bound or soluble peptide MHC class I donor antigens: factors relevant for the induction of rejection by indirect recognition

✍ Peter Terness; Christoph Dufter; Gerd Otto; Gerhard Opelz 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 576 KB

T cells recognize foreign antigens in the form of peptide fragments resulting from antigen processing by antigen-presenting cells. In contrast to this indirect recognition, MHC molecules of foreign cells can be directly recognized by T cells. Direct recognition has for a long time been considered th