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Factors relating to dramatic response to clobazam therapy in refractory epilepsy

✍ Scribed by A.J Heller; H.A Ring; E.H Reynolds

Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
386 KB
Volume
2
Category
Article
ISSN
0920-1211

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✦ Synopsis

Twenty-five out of 41 (61%) patients with drug-resistant complex partial seizures showed an initial dramatic response to clobazam. Sixteen of these responders developed tolerance to the effects of clobazam so that only 9 (22%) maintained a dramatic response for 1 year. Factors which appeared important in predicting a dramatic response to treatment were a known aetiology for the epilepsy, the occurrence of complex partial seizures alone (i.e., without secondary generalisation) and the absence of mental retardation.

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