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Factors influencing the identification of major genes in a complex disease genome scan

✍ Scribed by Huiying Yang; Yaping Wang; Darlene R. Goldstein; Zhiming Li; Hita Vora; Rita M. Cantor

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 52 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<933::aid-gepi62>3.0.co;2-m

No coin nor oath required. For personal study only.

✦ Synopsis

A two-stage linkage strategy was employed to identify major genes for a simulated complex disease via a genome scan. The importance of several approaches for improving the ability to locate major genes has been illustrated. These approaches are: adjusting for covariates, ascertaining through multiple affected family members, increasing the sample size, and using multipoint linkage analysis.

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