Factors influencing long-term survival following salvage total laryngectomy after initial radiotherapy or conservative surgery
✍ Scribed by B. Zach Fowler; Susan Muller; Amy Y. Chen; Peter A. S. Johnstone
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 106 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1043-3074
No coin nor oath required. For personal study only.
✦ Synopsis
Background:
This retrospective study investigated survival outcomes of salvage total laryngectomy (stl) after initial radiation therapy (rt) or larynx conservation surgery (cs) at an academic center.
Methods:
A chart review yielded 64 patients with stl: 53 with rt failures, six with cs failures, and five after rt + cs. median potential follow-up after stl was 9.4 years (mean, 9.2 years; range, 0.3-17.4 years).
Results:
Five- and 10-year actuarial overall survival (os) after stl was 65.2% and 37.7%, respectively. mean survival after stl was 7.2 years (median, 6.8 years; range, 0.2-17.4 years). no significant survival difference was found between the three treatment groups (p = .50). for 21 patients with nodes assessed at stl, 9-year os was 45.4% for patients with n0 disease versus 26.7% for patients with n+ disease (p = .25).
Conclusion:
These data suggest that stl after radiation failure is associated with equivalent long-term survival as stl after rt + cs or after failure of cs alone.