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Factors influencing antibody stability at solid–liquid interfaces in a high shear environment

✍ Scribed by James G. Biddlecombe; Graeme Smith; Shahid Uddin; Sandrine Mulot; David Spencer; Chris Gee; Brendan C. Fish; Daniel G. Bracewell

Publisher
American Institute of Chemical Engineers
Year
2009
Tongue
English
Weight
221 KB
Volume
25
Category
Article
ISSN
8756-7938

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✍ J. S. Harrison; A. Gill; M. Hoare 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 47 KB 👁 1 views

The effect of shear on the antigen binding activity of a recombinant scFv antibody fragment was investigated in the presence of air-liquid interfaces using a stirred vessel that was incompletely filled. Changes in binding activity of the scFv to its antigen were monitored using an optical biosensor