✦ LIBER ✦
Factors defining target specificity in antibody-mediated neuropathy: Density-dependent binding of anti-GD1a polyclonal IgG from a neurological patient
✍ Scribed by D.M. Kremer; P.H.H. López; R.K. Mizutamari; L.J. Kremer; E.A. Bacile; G.A. Nores
- Book ID
- 101244430
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 216 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0360-4012
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✦ Synopsis
IgM and IgG antibodies reacting with components of human brain gangliosides were detected in a patient bearing severe sensory ataxy. Using different chemical and immunological methods, the antigen was identified as the GD 1a ganglioside. The antibodies showed antigen ''density-dependent'' binding, a property only observed in tumor-specific monoclonal antibodies. The relevance of this result in regard with target specificity of neuropathy-associated antibodies directed to ubiquitous glycolipids is discussed.