Factors controlling the selectivity and efficiency of tumour damage in photodynamic therapy
β Scribed by Giulio Jori
- Publisher
- Springer-Verlag
- Year
- 1990
- Tongue
- English
- Weight
- 543 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0268-8921
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π SIMILAR VOLUMES
The uptake and biological activity of porphyrins and phthalocyanines in tumours were correlated with the geometrical features of the photosensitizer molecules. The data suggest that a critical distance of approximately 1.2 nm between oxygen atoms (originating in SO3-, COO- or OH substituents) charac
Zn(II)-phthalocyanine (ZnPc) and its octapentyl (ZnOPPc) and octadecyl (ZnODPc) derivatives have been intravenously injected at a dose of 1.46 ixmol/kg into female Balb/c mice bearing an intramuscularly transplanted MS-2 fibrosarcoma. Pharmacokinetic studies show that in all cases the maximal concen
## Abstract ## Background and Objective The main factors in photodynamic therapy (PDT) are: photosensitizer retention, photon absorption, and oxygen supply. Each factor has its unique set of problems that poses limitation to the treatment. Both light delivery and oxygen supply are significant bott