Factors contributing to ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C
β Scribed by Shintaro Takaki; Akihito Tsubota; Tetsuya Hosaka; Norio Akuta; Takashi Someya; Masahiro Kobayashi; Fumitaka Suzuki; Yoshiyuki Suzuki; Satoshi Saitoh; Yasuji Arase; Kenji Ikeda; Hiromitsu Kumada
- Publisher
- Springer Japan
- Year
- 2004
- Tongue
- English
- Weight
- 209 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0944-1174
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## Abstract Patients with high viral load (β₯1.0βΓβ10^5^ IU/ml) of hepatitis C virus (HCV) genotype 1b do not achieve high sustained virological response rates to interferon (IFN)/ribavirin combination therapy. Previous studies suggested that pretreatment amino acid (aa) substitution patterns in the
Ten patients with chronic hepatitis C, six of whom had not responded and four of whom had responded in a non-sustained fashion to interferon-alpha treatment alone, were given interferon alpha-2b and ribavirin in combination during 24 weeks. Interferon alpha-2b was given subcutaneously, at a dose of
## Abstract The aim of this study was to compare the efficacy of highβdose interferon (IFN)βΞ±β2b with standard dose of IFNβΞ±β2b in combination with ribavirin (RBV) for patients with chronic hepatitis C virus (HCV) infection, and to investigate the predictive factors associated with virological resp