Factors affecting transdermal delivery of metoprolol by electroporation
✍ Scribed by Rita Vanbever; Véronique Préat
- Book ID
- 103677213
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 534 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1567-5394
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Transdermal transport of insulin and extraction of interstitial glucose under anodal iontophoresis (electroosmosis) following electroporation in the presence of 1,2-dimyristoylphophatidylserine (DMPS) was studied. An earlier study showed that DMPS increased the transport of insulin across porcine ep
A previous study indicated that the parameters governing the performance of electroporative delivery to the skin, are voltage, pulse length, number of pulses and electrode area. 1 This article describes a study in which the reversibility of the electroporation technique is evaluated with in vitro me
The effect of different factors on the iontophoretic transport of metoprolol was analyzed. In vitro experiments were first performed in a diffusion cell with a cellophane membrane. Comparison of different pH, buffers, and ionic strengths in the donor compartment showed that higher iontophoretic tran