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Factors affecting the structure and properties of an injectable self-setting calcium phosphate foam

✍ Scribed by Maria-Pau Ginebra; José-Angel Delgado; Ingela Harr; Amisel Almirall; Sergio Del Valle; Josep A. Planell

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
528 KB
Volume
80A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

One of the main challenges in the investigation on calcium phosphate cements (CPC) lies in the introduction of macroporosity, without loosing the self‐setting ability and injectability, characteristic of the cement‐type materials. The benefits of macroporosity are related to the enhancement of bone regeneration mechanisms, such as angiogenesis and tissue ingrowth. In this work, the feasibility to obtain self‐setting injectable macroporous hydroxyapatite foams by the incorporation of a protein‐based foaming agent to a CPC is demonstrated. Albumen is combined with an α‐tricalcium phosphate [Ca~3~(PO~4~)~2~, α‐TCP] paste, which hydrolyzes to a calcium deficient hydroxyapatite during the setting reaction. A systematic study is presented, where the effect of different processing parameters is analyzed in terms of porosity, setting properties, injectability, and compressive strength. Self‐setting foams with porosities up to 70%, which maintain their porous structure after injection, are obtained. These injectable foams can be used both for direct in vivo applications and for the fabrication of low temperature tissue engineering scaffolds. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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