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Factors affecting the deamidation of vancomycin in aqueous solutions

โœ Scribed by Amy S. Antipas; David Vander Velde; Valentino J. Stella

Book ID
113367880
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
560 KB
Volume
109
Category
Article
ISSN
0378-5173

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๐Ÿ“œ SIMILAR VOLUMES

Effect of conformation on the rate of de
Effect of conformation on the rate of deamidation of vancomycin in aqueous solutions
โœ Amy S. Antipas; David G. Vander Velde; Seetharama D. S. Jois; Teruna Siahaan; Va ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 236 KB ๐Ÿ‘ 2 views

The instability of vancomycin, a glycopeptide antibiotic, limits its shelf-life because the deamidation of its asparagine residue results in the formation of a zwitterion with limited aqueous solubility. Analysis of the pH-rate profile for vancomycin indicates that the deamidation reaction is notabl