Factors affecting 39K NMR detectability in rat tissue

✍ Scribed by S. Abdul Rashid; W. R. Adam; D. J. Craik; B. P. Shehan; R. M. Wellard

• Book ID: 102955661
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 638 KB
• Volume: 17
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910170124

✦ Synopsis

In this study we have found that NMR detectability of 39K in rat thigh muscle may be substantially higher (up to 100% of total tissue potassium) than values previously reported of around 40%. The signal was found to consist of two superimposed components, one broad and one narrow, of approximately equal area. Investigations involving improvements in spectral parameters such as signal-to-noise ratio and baseline roll, together with computer simulations of spectra, show that the quality of the spectra has a major effect on the amount of signal detected, which is largely due to the loss of detectability of the broad signal component. In particular, lower-field spectrometers using conventional probes and detection methods generally have poorer signal-to-noise and worse baseline roll artifacts, which make detection of a broad component of the muscle signal difficult.