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Factor XI deficiency in women

✍ Scribed by Kadir, R.A.; Economides, D.L.; Lee, C.A.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 50 KB
Volume: 60
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199901)60:1<48::aid-ajh8>3.0.co;2-q

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✦ Synopsis

Factor XI (FXI) deficiency is an uncommon autosomally transmitted coagulopathy found predominantly in Jewish kindreds. It is associated with variable bleeding tendency that usually manifests after trauma, surgery, or other challenges to hemostasis. Therefore, women with FXI deficiency are at risk of excessive bleeding during their menstrual periods, childbirth, and after surgery. Increased awareness and close collaboration among hematologists, obstetricians, and gynecologists and availability of management guidelines is essential to minimize these risks. This review provides data from current research in FXI deficiency and pregnancy care, menstrual problems, and the role of screening for this disorder in women referred with menorrhagia. Am.

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