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Factor VIII Inhibitor bypassing activity: A suggested mechanism of action

✍ Scribed by T.W. Barrowcliffe; G. Kemball-Cook; E. Gray


Book ID
119035350
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
394 KB
Volume
21
Category
Article
ISSN
0049-3848

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πŸ“œ SIMILAR VOLUMES


Activation of factor VIII and mechanisms
✍ Philip J Fay πŸ“‚ Article πŸ“… 2004 πŸ› Elsevier Science 🌐 English βš– 495 KB

The factor VIII procofactor circulates as a metal ion-dependent heterodimer of a heavy chain and light chain. Activation of factor VIII results from limited proteolysis catalyzed by thrombin or factor Xa, which binds the factor VIII substrate over extended interactive surfaces. The proteases efficie