Factor VII polymorphisms influence the plasma response to diets with different fat content, in a healthy Caucasian population
✍ Scribed by Rafael Ángel Fernández de la Puebla; Pablo Pérez-Martínez; José Carmona; José López-Miranda Carmen Marín; Juan Antonio Paniagua; Francisco Fuentes; Francisco Pérez-Jiménez
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 229 KB
- Volume
- 51
- Category
- Article
- ISSN
- 1613-4125
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✦ Synopsis
Abstract
To determine the influence of the factor VII gene polymorphisms, R353Q and 5'F7, on factor VII Ag plasma levels after the consumption of diets with different fat contents. Methods: 59 healthy individuals (42 RR, 16 RQ, 1 QQ at the R353Q and 46 A1A1, 13 A1A2 at the 5'F7) consumed 3 diets during 4‐weeks each: a Saturated diet (SAT) enriched in saturated fatty acid (SFA) (38% fat, 20% SFA), followed by a carbohydrate (CHO)‐rich diet (30% fat, 55% CHO) or a Mediterranean diet (MEDIT) enriched in monounsaturated fatty acid (MUFA) (38% fat, 22% MUFA) following a randomized crossover design. Plasma lipids and FVII Ag plasma levels were determined at the end of each dietary period. Results: After a SAT diet, RR homozygotes had greater concentrations of FVII Ag compared with MEDIT and CHO diets than did carriers of the minority Q allele (82.76 ± 1.3 vs. 75.02 ± 2.4, p = 0.001). The 5'F7 polymorphism behaved in a similar fashion (A1A1 81.98 ± 1.4 vs. A1A2 75.37 ± 2.4, p = 0.026). Conclusions: Our data show that carriers of the RR and/or A1A1 genotype present higher FVII Ag levels after the consumption of a SAT diet compared with the MEDIT and CHO rich diets.