Factor V leiden mutation does not account for central venous catheter-related thrombosis

✍ Scribed by Riordan, Michele; Weiden, Paul L.

• Book ID: 101215083
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 15 KB
• Volume: 58
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199806)58:2<150::aid-ajh13>3.0.co;2-f

✦ Synopsis

Indwelling central venous access devices are frequently associated with catheter-related thrombosis. The factor V Leiden gene mutation decreases the sensitivity of factor V to the anticoagulant activity of activated protein C, and has been shown to be the most common inherited defect associated with a hypercoagulable state. In this study, we sought to determine whether an increased prevalence of the factor V gene mutation could be identified in individuals with malignancies who had catheter-related thrombosis. Twentyseven patients who had catheter-related thrombosis were identified and two (7%) tested positive for the heterozygous presence of the factor V gene mutation. Since the vast majority of patients with venous access devices who developed catheter-related thrombosis did not have the factor V gene mutation, pre-catheter placement testing for this mutation would have limited clinical utility. Am.