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Facilitation of proteasomal degradation of p27Kip1 by N-terminal cleavage and their sequence requirements

✍ Scribed by Katsuya Hirano; Eikichi Ihara; Mayumi Hirano; Junji Nishimura; Hajime Nawata; Hideo Kanaide


Book ID
116464801
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
289 KB
Volume
574
Category
Article
ISSN
0014-5793

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## Abstract p27^Kip1R^ is an isoform of p27^Kip1^, having a distinct C‐terminus. The sequences of p27^Kip1R^ required for nuclear localization and growth inhibition were determined in HeLa cells using a green fluorescence protein (GFP) as a reporter molecule. Region 153–168 and residues K168 and I1

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