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Facilitation of polyoma tumor growth in rats by blocking sera and tumor eluate

✍ Scribed by S. C. Bansal; R. Hargreaves; H. O. Sjögren

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
798 KB
Volume
9
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

It has been shown previously that sera of tumor‐bearing individuals are capable of blocking specifically the lymphocyte cytotoxicity in vitro against the tumor cells in question. The present investigation demonstrates that blocking material, in the form of sera of rats carrying progressively growing polyoma tumors and low p^H^ eluates of polyoma tumor tissue inoculated into polyoma isografted rats, cause an enhanced tumor growth. Corresponding serum from rats carrying an MCA‐induced sarcoma and eluate from such tumor tissue had no significant enhancing effect. The administered blocking activity was detectable in the sera of the recipients for 3 days after inoculation. No delay or decrease in the level of cell‐mediated anti‐tumor immunity could be detected by in vitro tests for lymphocyte cytotoxicity against polyoma tumor cells. This indicates that the mechanism of the facilitated tumor growth in vitro is akin to a central or an efferent type of enhancement.

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