Facilitation of opiate-and enkephalin-induced motor activity in the mouse by phenytoin sodium and carbamazepine

✍ Scribed by R. J. Katz; Kristine Schmaltz

• Book ID: 104786335
• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 461 KB
• Volume: 65
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00491980

✦ Synopsis

In the first experiment, adult male Swiss-Webster mice were systemically injected with a standard dose of morphine. Compared to the influence of vehicle, the motor activity of morphine-injected mice was increased. Neither phenytoin sodium nor carbamazepine alone facilitated motor activity, but pretreatment with both drugs further facilitated the increased motor activity produced by morphine. In a second experiment, mice were injected centrally with a longacting analog ofleu-enkephalin. It also increased motor activity in comparison with vehicle~ Again, both phenytoin sodium and carbamazepine further facilitated this response. Both experiments suggest a facilitatory interaction between some aspects of these anticonvulsants and opiate-induced motor activity.