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Facile Synthetic Access to and Biological Evaluation of the Macrocyclic Core of Apoptolidin

✍ Scribed by Wender, Paul A.; Jankowski, Orion D.; Tabet, Elie A.; Seto, Haruo


Book ID
115499104
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
76 KB
Volume
5
Category
Article
ISSN
1523-7060

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A facile and efficient synthetic approac
✍ Ashraf A. Abbas; Ahmed H. M. Elwahy; Ahmed A. M. Ahmed πŸ“‚ Article πŸ“… 2005 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 152 KB

The hydroxy macrocycles 8, 19a-c were prepared in 40-55% yields by reacting the dipotassium salts 2a-c with each of epichlorohydrin (7) and bis(chloromethyl) derivative 18. Acylation of the hydroxyl group of each of 8, 19a-c with 2-chloroacetylchloride (9) in DMF gave the corresponding esters 10, 20