Facile synthesis of new organophosphorus compounds with -N-P(O)-N- linkage: Reaction between 2-pyrazoline and phosphorodichloridates/phosphonic dichloride

✍ Scribed by K. V. Raghu; C. Devendranath Reddy; K. S. Rao

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 133 KB
• Volume: 8
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/(sici)1098-1071(1997)8:1<55::aid-hc8>3.0.co;2-1

✦ Synopsis

Condensation of 3-benzoyl-4-phenyl-2-pyrazoline with various aryl phosphorodichloridates or trichloromethylphosphonic dichloride in the presence of a base resulted in the formation of arylbis (3-benzoyl-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl)phosphinates and trichloromethyl-bis(3-benzoyl-4,5-dihydro-4-phenyl-1Hpyrazol-1-yl)phosphonate. The structures of the title compounds were confirmed by elemental analyses, IR, 1 H, 13 C, and 31 P NMR spectra. The EI mass spectrum of one member of the family is discussed. These compounds were found to possess good antibacterial and antifungal activity.