𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Facile synthesis of N-Cbz-α-dehydroamino acids and their dipeptide derivatives

✍ Scribed by Chung-gi Shin; Yasuchika Yonezawa; Kazuo Unoki; Juji Yoshimura

Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
120 KB
Volume
20
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

N-Cbz-a-dehydroamino acids (DHA) were prepared by the condensation of aketo acid with benzyl carbamate by one step and the subsequent coupling of the DHA with L-a-amino acid esters was carried out to give many kinds of dehydrodipeptides Recently, much interest has been directed to the dehydropeptide (DHP), which

📜 SIMILAR VOLUMES

Synthesis of dehydroamino acids and dide
Synthesis of dehydroamino acids and didehydrodioxopiperazines and their conversion into α-mercapto-α-amino acid derivatives
✍ Jacobus D. M. Herscheid; Henk P. H. Scholten; Marian W. Tijhuis; Harry C. J. Ott 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 600 KB

## Abstract A synthesis of α,β‐dehydroamino acid derivatives **12** is described, which is of possible general applicability and might be useful for the preparation of peptides which have such a moiety in their sequence. In addition, several didehydrodioxopiperazines (**13–17**) have been prepared.

Unusual amino acids VI. Substituted aryl
Unusual amino acids VI. Substituted arylamino acids by asymmetric hydrogenation of N-Cbz and N-Boc protected dehydroamino acid derivatives
✍ H. W. Krause; H.-J. Kreuzfeld; U. Schmidt; CH Döbler; M. Michalik; S. Taudien; C 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 997 KB

Substituted N-Cbz and N-Boc protected arylamino acrylic acids and esters have been prepared and used in asymmetric hydrogenations catalyzed by PROPRAPHOS-Rh. Stereoselectivities > 90% ee could be achieved, the rate of which is dependent on the position of the substituent in the aromatic ring. The N-