✦ LIBER ✦

Facile synthesis of a cis–syn thymine dimer building block and its incorporation into oligodeoxynucleotides

✍ Scribed by Javier Ulises Ortiz Mayo; Martial Thomas; Carole Saintomé; Pascale Clivio

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 279 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)01132-3

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✦ Synopsis

The synthesis of a building block containing the photobiologically relevant cissyn thymine cyclobutane photoproduct and its incorporation into oligonucleotides by the phosphoramidite-based solid-phase synthesis is reported. Compared to previous syntheses, this route is extremely short and allows such modified oligonucleotides to be easily available for biological studies.

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