Facile synthesis of 6,6,8,6,6-ring fused pentacyclic heterocycles: annelation of quinolines to quinoxalines under PTC condition

✍ Scribed by Priyankar Paira; Rupankar Paira; Abhijit Hazra; Subhendu Naskar; Krishnendu B. Sahu; Pritam Saha; Shyamal Mondal; Arindam Maity; Sukdeb Banerjee; Nirup B. Mondal

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 864 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.05.103

✦ Synopsis

An efficient and simple synthesis of pentacyclic quinolonoquinoxalinooxazocines in a one-pot sequence has been performed by unique application of phase transfer catalysis. Preparative simplicity and conceptual novelty of the methodology offer an attractive general application for the synthesis of novel quinoline antibiotics.