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Facile synthesis of 3-spiroindolines

✍ Scribed by Yehia A. Allam; Galal A. M. Nawwar

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
136 KB
Volume
13
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Cyanoacetyldiazoindol‐2‐one (3), the condensation product of cyanoacetohydrazide with isatin (1), could be cyclized in acidic medium via its CN group and its enolic OH to give cyanomethyloxadiazole‐spiroindoline (4). The presence of the methylcyano side chain could be invested—through oximation, diazotization, or condensation with aldehydes—to form polyfunctional spiroindolines 5, 8–10. Also, a second route for preparing the title compound could be achieved through a nucleophilic attack on position 3 in the isatin derivatives, followed by subsequent ring closure to give 6 and 7. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:207–210, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10020

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