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Facile synthesis of 2Z-2-Chloromethyl aryl-2-enoates

✍ Scribed by Subhash P. Chavan; Krishna S. Ethiraj; Subhash K. Kamat


Book ID
104258048
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
113 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis


Triethylamine -Methanesuifonyl chloride has been employed as reagent for stereoselective synthesis of 2Z-2-(Chloromethyl)aryl-2-enoates from Baylis Hillman products in good yields at room temperature.


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## Abstract Ethyl 2‐(chloromethyl)‐2‐hydroxy‐2__H__‐chromene‐3‐carboxylates **2a**–**2j** have been synthesized by reaction of substituted salicylaldehydes with ethyl 4‐chloro‐3‐oxobutanoate, in the presence of piperidine in CH~2~Cl~2~ at room temperature, in good yields.