Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
✍ Scribed by Sumangala, V.; Poojary, Boja; Chidananda, N.; Arulmoli, T.; Shenoy, Shalini
- Book ID
- 119233992
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 216 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0223-5234
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## Abstract magnified image A series of novel 6‐aryl‐3‐(1,2,3,4‐tetrahydroxybutanol‐1‐yl)‐7__H__‐1,2,4‐triazolo[3,4‐__b__][1,3,4]thiadiazines were easily synthesized in high yields by means of the reactions of 4‐amino‐5‐(1,2,3,4‐tetrahydroxybutyl)‐2,4‐dihydro‐3__H__‐1,2,4‐triazole‐3‐thione (**1**)
## Abstract [1,2,4]Triazolo[3,4‐b][1,3,4]thiadiazines **2a**, **2b**, **2c**, **2d**, **2e**, **2f** and 3,7‐dimethyl‐4__H__‐[1,2,4]triazino[3,4‐b][1,3,4]thiadiazin‐6‐one **4** were synthesized by one‐pot cyclocondensation reaction with α‐chloroacetonitrile and α‐haloketones in the presence of cata