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Facile Route to 3,5-Disubstituted Morpholines: Enantioselective Synthesis of O-Protected trans-3,5-Bis(hydroxymethyl)morpholines

✍ Scribed by Dave, Rajesh; Sasaki, N. André


Book ID
111864285
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
95 KB
Volume
6
Category
Article
ISSN
1523-7060

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## Abstract The reaction of thiocarbohydrazide with carboxylic acids at the melting temperature allows an improved preparation of the S‐substituted 4‐amino‐3‐mercapto‐1,2,4‐triazole heterocycles. The crude 4‐amino‐5‐mercapto‐1,2,4‐triazoles react easily with carboxylic acids or carboxylic acid chlo