Regioselective N-alkylation of imidazo[4
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Wael Zeinyeh; Julien Pilmรฉ; Sylvie Radix; Nadia Walchshofer
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Article
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2009
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Elsevier Science
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French
โ 460 KB
S N 2 mechanism Tautomerism a b s t r a c t Regioselectivities were determined for N-alkylations of imidazo [4,5-b]pyridine-4-oxide and 2-methylimidazo [4,5-b]pyridine-4-oxide with benzyl bromide or benzyl iodide at RT using K 2 CO 3 in DMF as a base. Experimental attempts have shown that N-1/N-3 ra