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Facile, Regioselective Syntheses of N-Alkylated 2,3-Diaminopyridines and Imidazo[4,5-b]pyridines

โœ Scribed by Khanna, Ish K.; Weier, Richard M.; Lentz, Kirk T.; Swenton, Lydia; Lankin, David C.


Book ID
120538462
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
790 KB
Volume
60
Category
Article
ISSN
0022-3263

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Regioselective N-alkylation of imidazo[4
โœ Wael Zeinyeh; Julien Pilmรฉ; Sylvie Radix; Nadia Walchshofer ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 460 KB

S N 2 mechanism Tautomerism a b s t r a c t Regioselectivities were determined for N-alkylations of imidazo [4,5-b]pyridine-4-oxide and 2-methylimidazo [4,5-b]pyridine-4-oxide with benzyl bromide or benzyl iodide at RT using K 2 CO 3 in DMF as a base. Experimental attempts have shown that N-1/N-3 ra